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TLR3/dsRNA Complex Inhibitor

≥99% (HPLC), solid, TLR3/dsRNA complex inhibitor, Calbiochem®

Sinônimo(s):

TLR3/dsRNA Complex Inhibitor, ( R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

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About This Item

Fórmula empírica (Notação de Hill):
C18H13ClFNO3S
Peso molecular:
377.82
Código UNSPSC:
12352200
NACRES:
NA.28

product name

TLR3/dsRNA Complex Inhibitor, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.

Nível de qualidade

100

Ensaio

≥99% (HPLC)

forma

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
protect from light

cor

white

solubilidade

DMSO: 50 mg/mL

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

Descrição geral

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >>100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Cheng, K., et al. 2011. J. Am. Chem. Soc.133, 3764.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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