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521233

Sigma-Aldrich

PDGFR Tyrosine Kinase Inhibitor IV

Sinônimo(s):

PDGFR Tyrosine Kinase Inhibitor IV, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409

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About This Item

Fórmula empírica (Notação de Hill):
C18H16FN3O2
Número CAS:
627518-40-5
Peso molecular:
325.34
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Nível de qualidade

100

forma

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
protect from light

cor

off-white

solubilidade

DMSO: 10 mg/mL
methanol: 5 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

−20°C

InChI

1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)

chave InChI

ZDNURMVOKAERHZ-UHFFFAOYSA-N

Descrição geral

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50<33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk′s-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).

Ações bioquímicas/fisiológicas

Cell permeable: yes
Primary Target
PDGFR Tyrosine Kinase
Product competes with ATP.
Reversible: yes
Target IC50: 4.2 nM and 45 nM for -β and -α form of PDGFR, respectively

Embalagem

Packaged under inert gas

Advertência

Toxicity: Harmful (C)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Ho, C.Y., et al. 2005. J. Med. Chem.48, 8163.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

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