506163

p38 MAP Kinase Inhibitor VIII

The p38 MAP Kinase Inhibitor VIII, also referenced under CAS 321351-00-2, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): p38 MAP Kinase Inhibitor VIII, (4-((2-Amino-4-bromophenyl)amino)-2-chlorophenyl)-(2-methylphenyl)methanone
• Fórmula empírica (Notação de Hill): C₂₀H₁₆BrClN₂O
• Número CAS: 321351-00-2
• Peso molecular: 415.71
• Número MDL: MFCD11100188
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: ethanol: 15 mg/mL; DMSO: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Brc1cc(c(cc1)Nc2cc(c(cc2)C(=O)c3c(cccc3)C)Cl)N
• InChI: 1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
• chave InChI: HDCLCHNAEZNGNV-UHFFFAOYSA-N

Descrição

Descrição geral

A cell-permeable aminobenzophenone compound that acts as a potent, ATP-binding pocket-targeting inhibitor against p38α and p38β₂ (82% and 93% inhibition with 1 µM inhibitor, respectively; IC₅₀ of p38α inhibition = 40 nM) with little activity against a panel of 57 other kinases, including p38γ, p38δ, Erk1/2, and JNK1. Shown to inhibit LPS-induced cytokine productions in human PBMC′s in vitro and exhibit in vivo efficacy in both acute and chronic murine models of skin inflammation.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Ottosen, E.R., et al. 2003. J. Med. Chem.46, 5651.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable