490070

Nitric Oxide Synthase, Neuronal Inhibitor I

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinônimo(s): Nitric Oxide Synthase, Neuronal Inhibitor I, (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
• Fórmula empírica (Notação de Hill): C₈H₂₁N₇O₂ · 3C₂HF₃O₂ · 2H₂O
• Número CAS: 357965-99-2
• Peso molecular: 625.40
• Número MDL: MFCD05865227
• Código UNSPSC: 12352303
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: white to off-white
• solubilidade: water: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.[N+](=O)(N\C(=N\CCC[C@H](N)CNCCN)\N)[O-]
• InChI: 1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1
• chave InChI: NYWNMNBIORWOSQ-QTPLPEIMSA-N

Descrição

Descrição geral

A cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (K_i = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.

A cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (K_i = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
nNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 120 nM against nNOS

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

forma física

Supplied as a dihydrate.

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Hah, J.M., et al. 2001. J. Med. Chem.44, 2667.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable