N2783
Nitric Oxide Synthase, Inducible from mouse
recombinant, expressed in E. coli, buffered aqueous solution
Sinônimo(s):
Inducible Nitric Oxide Synthase, NOS II, iNOS, macNOS
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
50 UNITS
R$ 2.864,00
Selecione um tamanho
Alterar visualização
50 UNITS
R$ 2.864,00
About This Item
Número da licença da enzima:
Número MDL:
Código UNSPSC:
12352303
NACRES:
NA.32
Produtos recomendados
recombinante
expressed in E. coli
Nível de qualidade
Formulário
buffered aqueous solution
atividade específica
≥4.0 units/mg protein
peso molecular
130 kDa (homodimer)
130 kDa (subunit, homodimer)
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
mouse ... Nos2(18126)
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
Inducible nitric oxide synthase (iNOS), also known as inflammatory nitric oxide synthase, is a calcium independent isoenzyme, involved in synthesis of nitric oxide (NO). It is a soluble enzyme encoded by the gene mapped to mouse chromosome 11.[1] iNOS is active in dimeric form and its activity is induced by cytokines and various other stimuli.[1][2][3] iNOS is expressed in various inflammatory conditions.[3]
Aplicação
Nitric Oxide Synthase, Inducible from mouse has been used in immunohistochemical studies.[4] It is also used to evaluate the therapeutic efficacy of inducible nitric oxide synthase (NOS) on reperfusion-induced microcirculatory alterations and hemodynamic adverse effects in the microvasculature of skeletal muscle.[5]
Ações bioquímicas/fisiológicas
NOS is responsible for the biosynthesis of nitric oxide from L-arginine. iNOS is not calcium/calmodulin dependent and has a Km = 16 μM for L-arginine.
Tumor-derived inducible nitric oxide synthase (iNOS) plays a vital role in stimulating tumor growth and vessel maturation. Therefore, it is considered to be a potential therapeutic target for anti-vascular cancer therapies.[6] Unchecked activity of iNOS leads to overproduction of nitric oxide (NO), which is toxic for living cells. iNOS activity can be controlled at both transcription and translational level by regulating protein stability, dimerization, phosphorylation, cofactor binding and availability of oxygen and L-arginine as substrates.[2] iNOS plays a vital role in excisional wound repair and exhibits gene therapy strategy to advance wound healing process in iNOS-deficient conditions such as diabetes and steroid treatment.[3]
Definição da unidade
One unit will produce 1.0 μmol of nitric oxide per minute at 37 °C in 50 mM HEPES, pH 7.4, containing 1 mM arginine, 1 mM magnesium acetate, 0.15 mM NADPH, 4.5 μM oxyhemoglobin, 18 μM tetrahydrobiopterin and 180 μM DTT.
forma física
Solution in 50 mM HEPES, pH 7.4, with 10% glycerol, 8 μM tetrahydrobiopterin
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Certificados de análise (COA)
Lot/Batch Number
Não está vendo a versão correta?
Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Investigating the role of tumour cell derived iNOS on tumour growth and vasculature in vivo using a tetracycline regulated expression system.
Papaevangelou E
International Journal of Cancer. Journal International Du Cancer, 138(11), 2678-2687 (2016)
Mapping of the gene for inducible nitric oxide (NO) synthase of mouse macrophages to chromosome 11, close to Evi-2, nu, and Idd-4.
Jenkins NA
Genomics, 19(2), 402-404 (1994)
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.
Yamasaki K
The Journal of Clinical Investigation, 101(5), 967-971 (1998)
Nitric oxide and nitric oxide synthase during
early lactation in water buffalo dams
early lactation in water buffalo dams
M.E. Pero
Rev. Med. Vet. (Toulouse), 157, 16-19 (2006)
P A Marsden et al.
FEBS letters, 307(3), 287-293 (1992-08-03)
The constitutive calcium/calmodulin-dependent nitric oxide (NO) synthase expressed in vascular endothelium shares common biochemical and pharmacologic properties with neuronal NO synthase. However, recent cloning and molecular characterization of NO synthase from bovine endothelial cells indicated the existence of a family
Artigos
Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
