444151
Nutlin-3
InSolution, ≥98%, Racemic, potent and selective MDM2 antagonist
Sinônimo(s):
InSolution Nutlin-3, Racemic, MDM2 Inhibitor IV
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About This Item
Fórmula empírica (Notação de Hill):
C30H30Cl2N4O4
Peso molecular:
581.49
Código UNSPSC:
12352200
NACRES:
NA.77
Produtos recomendados
Nível de qualidade
Ensaio
≥98% (HPLC)
forma
liquid
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
desiccated (hygroscopic)
protect from light
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Descrição geral
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Embalagem
Packaged under inert gas
Advertência
Toxicity: Irritant (B)
forma física
A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Reconstituição
Following initial thaw, aliquot and freeze (-20°C).
Outras notas
Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.
Vassilev, L.T., et al. 2004. Science303, 844.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Ponto de fulgor (°C)
87 °C - closed cup - (Dimethylsulfoxide)
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