382180
Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda
Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda, is a full-length HDAC6 fused to GST at the N-terminus. Useful in the study of HDAC6 regulation and for inhibitor screening.
Sinônimo(s):
HDAC6, Human, Recombinant
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.54
Produtos recomendados
recombinante
expressed in insect cells (S. frugiperda)
Nível de qualidade
Ensaio
≥80% (SDS-PAGE)
forma
liquid
atividade específica
≥50 units/μg protein
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
avoid repeated freeze/thaw cycles
Condições de expedição
wet ice
temperatura de armazenamento
−70°C
Descrição geral
Full length, recombinant, human histone deacetylase 6 (HDAC6) fused to GST at the N-terminus and expressed in S. frugiperda insect cells using a baculovirus expression system. Actively maintained in the cytoplasm, HDAC6 is uniquely dependent on its ubiquitin-binding domain and functions at the nexus between two cellular signaling systems, involving protein acetylation and ubiquitination. The active deacetylase is useful in the study of HDAC6 regulation and for inhibitor screening.
Embalagem
Please refer to vial label for lot-specific concentration.
Advertência
Toxicity: Standard Handling (A)
Definição da unidade
One unit is defined as the amount of enyme that is required to deacetylate 1 pmol fluorescent HDAC peptide substrate per min at 30°C.
forma física
40 mM Tris-HCl pH8.0, 110mM NaCl, 2.2 mM KCl, 0.04% Tween 20, 3mM DTT, and 20% glycerol.
Reconstituição
Following initial thaw, aliquot and freeze (-70°C).
Outras notas
Pandey, U.B., et al. 2007. Nature447, 859.
Hubbert, C., et al. 2002. Nature417, 455.
Hubbert, C., et al. 2002. Nature417, 455.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Jin Kyun Park et al.
Arthritis research & therapy, 23(1), 177-177 (2021-07-07)
To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). FLS from RA patients were activated with interleukin (IL)-1β in the presence of increasing concentrations of
Nina Ha et al.
British journal of pharmacology, 177(22), 5096-5113 (2021-01-19)
Charcot-Marie-Tooth (CMT) disease is the most common hereditary peripheral neuropathy. CMT type 1A (CMT1A) accounts for approximately 50% of CMT patients and is linked to PMP22 gene duplication. Histone deacetylase-6 (HDAC6) has pleiotropic effects, such as regulating lipid homeostasis and
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