239805

Cyclopiazonic Acid, Penicillium cyclopium

A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca²⁺-ATPase that releases Ca²⁺ from the same intracellular pools as Thapsigargin.

• Sinônimo(s): Cyclopiazonic Acid, Penicillium cyclopium, CPA
• Fórmula empírica (Notação de Hill): C₂₀H₂₀N₂O₃
• Número CAS: 18172-33-3
• Peso molecular: 336.38
• Número MDL: MFCD00167445
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (TLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: off-white
• solubilidade: DMSO: 1 mg/mL; chloroform: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• InChI: 1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,25H,7H2,1-3H3/t12-,16+,17+/m1/s1
• chave InChI: RLOAZVAJNNPPDI-DQYPLSBCSA-N

Descrição

Descrição geral

A cell-permeable, reversible inhibitor of endoplasmic reticulum Ca²⁺-ATPase that releases Ca²⁺ from the same intracellular pools as thapsigargin. Mobilizes Ca²⁺ without increasing the levels of Ins(1,4,5)P₃. Also known to inhibit sarcoplasmic reticular Ca²⁺-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca²⁺ pools that have been depleted by repetitive stimulation with acetylcholine.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Ca²⁺ uptake in cultured arterial musclue cells

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells

Advertência

Toxicity: Toxic (F)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
Schaefer, A., et al. 1994. J. Biol. Chem.269, 8786.
Demaurex, N., et al. 1992. J. Biol. Chem.267, 2318.
Low, A.M., et al. 1992. Am. J. Physiol.262, H31.
Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil.12, 355.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 2 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable