23-041-M

c-Cbl Protein, active, 10 µg

Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

• Sinônimo(s): E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55
• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

Propriedades

• fonte biológica: human
• Nível de qualidade: 100; 300
• recombinante: expressed in baculovirus infected Sf21 cells
• fabricante/nome comercial: Upstate^®
• técnica(s): activity assay: suitable
• nº de adesão NCBI: NM_005188

Descrição

Descrição geral

Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

N-terminal cMyc and GST-tagged, recombinant human IKKγ full length, expressed by baculovirus in Sf21 insect cells.

Aplicação

Ubiquitination Cascade Comoponent: E3

forma física

Purified using glutathione sepharose.

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317
• Declarações de precaução: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classificações de perigo: Skin Sens. 1
• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable