208722

Calpain Inhibitor III

The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinônimo(s): Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, MDL 28170
• Fórmula empírica (Notação de Hill): C₂₂H₂₆N₂O₄
• Número CAS: 88191-84-8
• Peso molecular: 382.45
• Número MDL: MFCD00798796
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: lyophilized solid
• potência: 8 nM IC₅₀
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: white
• solubilidade: DMSO: 20 mg/mL (Use only anhydrous DMSO.)
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
• chave InChI: NGBKFLTYGSREKK-PMACEKPBSA-N

Descrição

Descrição geral

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
calpain 1, calpain 2

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Standard Handling (A)

Sequência

Z-Val-Phe-CHO

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Outras notas

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable