06-570-AF647

Anti-phospho Histone H3 (Ser10), Alexa Fluor^™ 647 Conjugate Antibody

0.5 mg/mL, from rabbit

• Sinônimo(s): H3S10P, Histone H3 (phospho Ser10), H3 histone, family 3A, H3.3A, H3 histone, family 3B, H3.3B
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: ALEXA FLUOR^™ 647
• forma do anticorpo: purified antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• reatividade de espécies: human
• reatividade da espécie (prevista por homologia): mouse (based on 100% sequence homology)
• concentração: 0.5 mg/mL
• técnica(s): immunocytochemistry: suitable
• nº de adesão NCBI: NP_003484.1
• nº de adesão UniProt: Q16695
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: phosphorylation (pSer10)
• Informações sobre genes: human ... HIST1H3F(8968)

Descrição

Descrição geral

Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 06-570.

Imunogênio

Linear peptide corresponding to Histone H3 phosphorylated at Ser10.

Aplicação

Anti-phospho-H3 (Ser10), Alexa Fluor^™ 647 Conjugate is a purified rabbit polyclonal antibody to detect Histone H3 phosphorylated at serine 10. This Ab is labeled with Alexa Fluor 647 and validated for use in IC. The unconjugated version of this antibody is published and proven in ICC, IP & WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Histones

Qualidade

Evaluated by Immunocytochemistry in HeLa cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected phospho Histone H3 (Ser10) in HeLa cells.

Alexa Fluor^™ is a registered trademark of Life Technologies.

Descrição-alvo

~17 kDa observed (Refer to Cat. No. 06-570)

forma física

Protein A purified

Purified rabbit conjugated antibody in buffer containing PBS and 15 mg/ml BSA with 0.1% Sodium Azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Informações legais

ALEXA FLUOR is a trademark of Life Technologies

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable