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D-063

Supelco

Dehydroepiandrosterone (DHEA) solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sinônimo(s):

Dehydroepiandrosterone

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About This Item

Fórmula empírica (Notação de Hill):
C19H28O2
Número CAS:
53-43-0
Peso molecular:
288.42
Número CE:
200-659-6
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material

forma

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

1.0 mg/mL in methanol

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing

formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1

chave InChI

FMGSKLZLMKYGDP-USOAJAOKSA-N

Categorias relacionadas

Descrição geral

DHEA is an endogenous steroid that has been implicated in a broad range of biological effects in humans and other mammals. Besides testing under the World Anti-Doping Code of the World Anti-Doping Agency (WADA), DHEA levels are also measured for newborn screening of congenital adrenal hyperplasia (CAH) and for determination of hyperandrogenic conditions such as polycystic ovarian syndrome and adrenal tumors. This calibration material is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports testing.

Aplicação

  • DHEA in Doping-Control: This research develops an extraction and GC-MS analysis method for anabolic steroids, including DHEA, in dietary supplements, aimed at doping control applications, enhancing the reliability of DHEA testing in sports science (Dahmani et al., 2018).
  • Chromatography for Hormonal Analysis: The development of a liquid chromatography-tandem mass spectrometry method for simultaneous measurement of testosterone, androstenedione, and DHEA in serum offers a robust tool for researchers studying steroid hormone pathways and their implications in various physiological processes (Xu et al., 2017).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes,Central nervous system

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

Certificados de análise (COA)

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Marta Kokot-Kierepa et al.
Ginekologia polska, 83(10), 772-777 (2013-02-07)
With increasing longevity in Poland, women can now expect to live around 40% of their lives after menopause, and there is a growing desire for older women to preserve their vitality sexual function and quality of life. The most common
Jean-Pierre Savineau et al.
Biochemical pharmacology, 85(6), 718-726 (2012-12-29)
Dehydroepiandrosterone (DHEA) is a steroid hormone derived from cholesterol synthesized by the adrenal glands. DHEA and its 3β-sulphate ester (DHEA-S) are the most abundant circulating steroid hormones. In human, there is a clear age-related decline in serum DHEA and DHEA-S
Elizabeth Huerta-García et al.
BioMed research international, 2013, 382058-382058 (2013-03-14)
Particulate matter (PM) and nanoparticles (NPs) induce activation and dysfunction of endothelial cells characterized by inhibition of proliferation, increase of adhesion and adhesion molecules expression, increase of ROS production, and death. DHEA has shown anti-inflammatory and antioxidant properties in HUVEC
E Borman et al.
Clinical and experimental obstetrics & gynecology, 39(4), 429-431 (2013-03-01)
To determine if in a population of women with diminished oocyte reserve as evidenced by day 3 serum follicle stimulating hormone (FSH) levels > 12 mIU/ml women with lower dehydroepiandrosterone sulfate (DHEA-s) levels produce fewer oocytes or have lower pregnancy
Abdallah Alzoubi et al.
American journal of physiology. Heart and circulatory physiology, 304(12), H1708-H1718 (2013-04-16)
Current therapy of pulmonary arterial hypertension (PAH) is inadequate. Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in chronically hypoxic and monocrotaline-injected rats. Contrary to these animal models, SU5416/hypoxia/normoxia-exposed rats develop a more severe form of occlusive pulmonary arteriopathy and right
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