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A-923

Supelco

Amitriptyline hydrochloride solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (Notação de Hill):
C20H24ClN
Número CAS:
549-18-8
Peso molecular:
313.86
Número CE:
200-659-6
Código UNSPSC:
41116107
NACRES:
NA.24

grau

certified reference material

forma

liquid

Características

SNAP-N-SPIKE®, SNAP-N-SHOOT®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

1.0 mg/mL in methanol

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing

formato

single component solution

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

chave InChI

KFYRPLNVJVHZGT-UHFFFAOYSA-N

Informações sobre genes

human ... SLC6A2(6530) , SLC6A4(6532)

Categorias relacionadas

Descrição geral

A Certified Spiking Solution® suitable for use in LC/MS or GC/MS applications in clinical toxicology, forensic analysis, urine drug testing, prescription monitoring or pharmaceutical research. Amitriptyline, marketed as the brand drug Elavil, Tryptizol, or Laroxyl, is a tricyclic antidepressant used in the treatment of major depression, clinical/endogenous depression and involutional melancholia.

Aplicação


  • Tricyclic antidepressant research: A study demonstrated the use of antisolvent precipitation to formulate excipient-free nanoparticles of psychotropic drugs, including amitriptyline hydrochloride, which could significantly impact the development of novel drug delivery systems for neuropharmacological applications (Wu and Wang, 2022).

  • Neuropharmacology amitriptyline: Research into micellar and interfacial phenomena of amitriptyline hydrochloride with cationic ester-bonded gemini surfactants explored its potential in enhancing drug solubility and stability, which is crucial for neuropharmacological studies and drug delivery systems (Abdul Rub, 2020).

  • Amitriptyline liquid formulation: A methodology to create polymeric nanocarriers containing hydrophilic low molecular-weight drugs, such as amitriptyline, offers a green strategy with very high drug loading, facilitating the development of amitriptyline-based formulations for pharmacological research (Villamizar-Sarmiento et al., 2019).

Informações legais

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órgãos-alvo

Eyes,Central nervous system

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

49.5 °F - closed cup

Ponto de fulgor (°C)

9.7 °C - closed cup

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Topical amitriptyline-ketamine for the treatment of brachioradial pruritus.
Timothy J Poterucha et al.
JAMA dermatology, 149(2), 148-150 (2013-02-22)
David Temesi et al.
Journal of pharmaceutical and biomedical analysis, 76, 164-168 (2013-01-22)
Procedures for drug monitoring based on Dried Blood Spot (DBS) sampling are gaining acceptance for an increasing number of clinical and preclinical applications, where ease of use, small sample requirement, and improved sample stability have been shown to offer advantages
[Sweating under polypharmacy with tramadol, amitriptyline and duloxetine?].
Gesine Picksak et al.
Medizinische Monatsschrift fur Pharmazeuten, 36(5), 195-196 (2013-06-14)
Seth M Cohen et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 148(3), 374-382 (2013-01-10)
The goal of this systematic review was to examine the evidence for the use of the neuromodulating agents, amitriptyline, gabapentin, pregabalin, and baclofen, in the management of chronic, idiopathic cough patients. Online databases, including PubMed, Embase, Cochrane Review, and Web
Christian Janfelt et al.
Journal of mass spectrometry : JMS, 48(3), 361-366 (2013-03-16)
Displaced dual-mode imaging (DDI) is introduced as a method for simultaneous imaging in positive and negative-ion mode on the same sample with desorption electrospray ionization imaging, as well as a method for simultaneous imaging in full-scan and tandem mass spectrometry
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