936189

AdQPhos

• Sinônimo(s): 1,2,3,4,5-Pentaphenyl-1′-(di-adamantylphosphino)ferrocene
• Fórmula empírica (Notação de Hill): C₆₀H₅₉FeP
• Peso molecular: 866.93
• Código UNSPSC: 12352142
• NACRES: NA.22

Propriedades

• Ensaio: ≥90%
• Nível de qualidade: 100
• adequação da reação: reaction type: Cross Couplings
• grupo funcional: phosphine
• cadeia de caracteres SMILES: c1(C2=CC=CC=C2)c(C3=CC=CC=C3)c(C4=CC=CC=C4)c(C5=CC=CC=C5)c1C6=CC=CC=C6.c7(P([C@]89C[C@H]%10C[C@H](C[C@H](C%10)C9)C8)[C@]%11%12C[C@H]%13C[C@H](C[C@H](C%13)C%12)C%11)cccc7.[Fe]

Descrição

Descrição geral

The precatalysts derived from AdQPhos exhibit excellent activity towards palladium-catalyzed α-arylation reactions under milder conditions. The strength of these catalytic systems in enabling such reactions were demonstrated with the broad scope of nucleophiles, including nitroalkanes, nitriles, amides, esters, and ketones. Compared to other state-of-the-art catalysts, this system was far superior and served as the first versatile catalytic system to accommodate all these nucleophiles in this context.

Further, by merging with micellar catalysis, this catalytic system demonstrated the feasibility of enabling α-arylation reactions under mild aqueous conditions. This approach provides an environmentally benign alternative to toxic/hazardous solvents like 1,4-dioxane or NMP, bringing modern organic synthesis closer to being ideally sustainable.

Aplicação

In addition to facilitating α-arylations, these catalysts demonstrate compatibility with various challenging cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig aminations, and C-O and C-S cross-couplings.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable