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Merck
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935441

Sigma-Aldrich

Aldehyde functionalized hyaluronic acid

Degree of functionalization ~20%

Sinônimo(s):

HA-A, Hyaluronic acid, Hyluronic acid aldehyde, Oxidized hyaluronic acid

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About This Item

Fórmula linear:
(C14H20NNaO11)n(C14H18NNaO11)m
Código UNSPSC:
12352201
NACRES:
NA.28

Nível de qualidade

forma

powder or chunks (or fibers)

cor

white to off-white

temperatura de armazenamento

−20°C

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Descrição geral

Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them potentially useful for their application in Tissue engineering. Partially oxidized hyaluronate (OHA) containing two highly aldehyde groups in the repeating unit of HA. The dialdehyde groups of OHA are capable of reductive coupling with primary amines and thus can be used in a wide range of chemical modifications of HA as hydrogel for tissue engineering applications and regenerative medicine drug delivery applications

Aplicação

HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.

Características e benefícios

  • Coupling capabilities with primary amines
  • Biocompatible functionalized natural polymer
  • Promotes a variety of cellular and tissue functions

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Visite a Biblioteca de Documentos

Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Sonia T, et al.
Pharmaceutics, 11, 407-407 (2019)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca G C, et al.
Polysaccharides, 2, 477-496 (2021)
Hyaluronic Acid and Controlled Release: A Review
Bayer S I, et al.
Molecules (Basel), 25, 2649-2649 (2020)
General Dialdehyde Click Chemistry for Amine Bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)

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