Sodium alginate is a natural linear polysaccharide derived from brown algae made up of blocks of B-D-mannuronate (M) and a-L-guluronate (G). Guluronate blocks that bind Ca2+ cations to form ionic bonds. Poly(guluronate) is isolated from alginate which can be used alone as a stabilizer or further modified to create additional functional groups.
Aplicação
Sodium Alginate based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.
Características e benefícios
Sterile, low endotoxin
Batch control offers reproducible models for preclinical toxicology testing and drug screening
Extended shelf-life & stability
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have
Journal of pharmaceutical sciences, 89(7), 910-919 (2000-06-22)
We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly(aldehyde guluronate). Adipic dihydrazide was used
Graft copolymers were prepared by formation of an amide bond between poly-α-L-guluronic acid (MW 24,000), isolated from sodium alginate and the free amino group of PNIPAAm-NH(2). SEM micrographs revealed the formation of a macroscopic network on the surface of the
Journal of biomedical materials research, 56(2), 228-233 (2001-05-08)
Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range
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