923834
Chitosan-mPEG 1k
25-60% PEGylation, medium MW
Sinônimo(s):
Medium MW, PEGylated Chitosan
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1 G
R$ 1.981,00
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1 G
R$ 1.981,00
About This Item
Fórmula linear:
(C8H13NO5)p((C2H4O)nC10H17NO6)m
Código UNSPSC:
12352201
NACRES:
NA.23
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Nível de qualidade
Formulário
solid (powder or chunk(s) or fiber)
cor
white to off-white
temperatura de armazenamento
2-8°C
Aplicação
- Chitosan has in the last decades been widely used in a variety of applications, both industrially and pharmaceutically.
- Its positive charges under slightly acidic conditions allow it to form complexes or nanoparticles.
- During the delivery process, the stable compact structure of the complex, with cationic chitosan chains as the outershell and the anionic genes/drugs as the core, efficiently protects genes/drugs from the ″sweeping effect″ of mucociliary clearance and degradation by enzymes.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Li Xiang et al.
Physical chemistry chemical physics : PCCP, 21(37), 20571-20581 (2019-08-01)
PEGylation can modify the physicochemical properties of native chitosan and improves its water solubility. PEGylated chitosan has been widely used as a gene/drug delivery vector by forming a polyelectrolyte complex (PEC) in biomedical engineering. The molecular interactions of PEGylated chitosan
Peggy Chan et al.
Biomaterials, 28(3), 540-549 (2006-09-27)
Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation may improve gene transfection efficiency due to promoted uptake of folate receptor-bearing
PEGylated chitosan derivatives:Synthesis, characterizations and pharmaceutical applications
Casettarietal L, et al.
Progress in Polymer Science, 37, 659-685 (2012)
H Ragelle et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 54-63 (2014-01-07)
This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood. Therefore, the influence of chitosan/tripolyphosphate ratio
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