901841

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average M_n 5,000, PCL average M_n 5,000

• Sinônimo(s): NHS ester PEG-PCL diblock copolymer, NHS ester-PEG-PCL, PEG-b-PCL, PEG-PCL
• Fórmula linear: C₁₀H₁₄NO₅S[C₂H₄O]_n[C₆H₁₀O₂]_mH
• Código UNSPSC: 12352005
• NACRES: NA.23

Propriedades

• Formulário: powder or solid
• peso molecular: PCL average M_n 5,000; PEG average M_n 5,000
• cor: white to off-white
• PDI: ≤1.3 (by GPC)
• temperatura de armazenamento: −20°C

Descrição

Aplicação

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The NHS ester functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable