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Merck
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Documentos

901209

Sigma-Aldrich

N-(But-3-yn-1-yl)-4-hydrazineylbenzamide hydrochloride

Sinônimo(s):

Clickable, nucleophilic hydrazine probe

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About This Item

Fórmula empírica (Notação de Hill):
C11H14ClN3O · xHCl
Número CAS:
Peso molecular:
239.70 (free base basis)
Código UNSPSC:
12352101

forma

powder or crystals

temperatura de armazenamento

2-8°C

Aplicação

Propylhydrazine can be used as a synthetic building blocks for various applications. Ben Cravatt′s lab recently developed clickable, nucleophilic hydrazine probes for "reverse-polarity" activity-based protein profiling, or (RP)-ABPP, where this propylhydrazine was used as a competitor for hydrazine probe 901210.

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Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Conteúdo relacionado

The aim of the Cravatt research group is to understand the roles that mammalian enzymes play in physiological and pathological processes and to use this knowledge to identify novel therapeutic targets for the treatment of human disease. To achieve these goals, they develop and apply new technologies that bridge the fields of chemistry and biology, ascribing to the philosophy that the most significant biomedical problems require creative multidisciplinary approaches for their solution. The group's technological innovations address fundamental challenges in systems biology that are beyond the scope of contemporary methods. For instance, enzymes are tightly regulated by post-translational events in vivo, meaning that their activity may not correlate with expression as measured by standard genomic and proteomic approaches. Considering that it is an enzyme's activity, rather than abundance that ultimately dictates its role in cell physiology and pathology, the Cravatt group has introduced a set of proteomic technologies that directly measures this parameter. These activity-based protein profiling (ABPP) methods exploit the power of chemistry to engender new tools and assays for the global analysis of enzyme activities. The enzyme activity profiles generated by ABPP constitute unique molecular portraits of cells and tissues that illuminate how metabolic and signaling networks are regulated in vivo. Additionally, by evaluating enzymes based on functional properties rather than mere abundance, ABPP acquires high-content proteomic information that is enriched in novel markers and targets for the diagnosis and treatment of human disease.

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