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765511

Sigma-Aldrich

Gold nanoparticles

20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Sinônimo(s):

Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid

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1 ML
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About This Item

Código UNSPSC:
12162002
NACRES:
NA.23

R$ 3.761,00

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Materiais

PEG 5000

Nível de qualidade

100

Formulário

dispersion in H2O
nanoparticles

embalagem

poly bottle of 1 mL

DO

50

diâmetro

20 nm

pH

6.0-8.0 (25 °C)

solubilidade

water: miscible

densidade

1.00 g/cm3

λmax

520 nm

grupo funcional

carboxylic acid

temperatura de armazenamento

2-8°C

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Descrição geral

Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.[1]

Aplicação

Carboxylic acid functionalized, PEG 5000 coated, OD 50, and H2O dispersed gold nanoparticles can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.[2]
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique.[3][4] It may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19.[5] It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.[5]
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
The carboxylic acid group binds with various proteins and can be used in targeted drug delivery and gene therapy. [6]

Características e benefícios

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. The PEG increases the stability of the nanoparticles and prevents agglomeration.[6]

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCQ4424
MKCW5552
MKBZ0088V
MKBL5794V

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Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 6, 2071-2071 (2020)
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
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Nag P, et al.
Transactions of the Indian National Academy of Engineering, 143(9), 1-4 (2020)
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