746061

Difluoromethyl 2-pyridyl sulfone

97% (HPLC)

• Sinônimo(s): 2-[(Difluoromethyl)sulfonyl]pyridine, Hu Reagent, 2-(Difluoromethylsulfonyl)pyridine, 2-PySO₂CF₂H
• Fórmula empírica (Notação de Hill): C₆H₅F₂NO₂S
• Número CAS: 1219454-89-3
• Peso molecular: 193.17
• Beilstein: 20317604
• Número MDL: MFCD17010193
• Código UNSPSC: 12352101
• ID de substância PubChem: 329765740
• NACRES: NA.22

Propriedades

• Nível de qualidade: 100
• Ensaio: 97% (HPLC)
• Formulário: solid
• pf: 44-49 °C
• grupo funcional: fluoro; sulfone
• cadeia de caracteres SMILES: O=S(C1=CC=CC=N1)(C(F)F)=O
• InChI: 1S/C6H5F2NO2S/c7-6(8)12(10,11)5-3-1-2-4-9-5/h1-4,6H
• chave InChI: YRQNSTAWTLXCEZ-UHFFFAOYSA-N

Descrição

Descrição geral

Difluoromethyl 2-pyridyl sulfone (2-PySO₂CF₂H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.[1][2]

Aplicação

Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions.[3] Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.[4]

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H319
• Declarações de precaução: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313 - P405
• Classificações de perigo: Acute Tox. 3 Oral - Eye Irrit. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable