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365602

Sigma-Aldrich

Sinomenine

0.3 mol chloroform of crystallization

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About This Item

Fórmula empírica (Notação de Hill):
C19H23NO4 · 0.3CHCl3
Número CAS:
115-53-7
Peso molecular:
365.20
Número MDL:
MFCD00134303
Código UNSPSC:
12352005
ID de substância PubChem:
24862546
NACRES:
NA.22

controle de medicamentos

regulated under CDSA - not available from Sigma-Aldrich Canada

Impurezas

0.3 mol chloroform of crystallization

pf

180 °C (dec.) (lit.)

grupo funcional

ether
ketone

cadeia de caracteres SMILES

COC1=CC2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O

InChI

1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1

chave InChI

INYYVPJSBIVGPH-QHRIQVFBSA-N

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Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Órgãos-alvo

Liver,Kidney, Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
16127DZ
07415CU
03216DY

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Meng-Xiang Su et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 889-890, 39-43 (2012-02-22)
A sensitive and selective liquid chromatographic tandem mass spectrometric method was developed and validated for the determination of sinomenine in human plasma. Plasma samples were precipitated using methanol with metronidazole as internal standard. Separation was carried out on an Inertsil
Peng Teng et al.
European journal of medicinal chemistry, 50, 63-74 (2012-02-14)
Sinomenine (1) is clinically available for the treatment of rheumatoid arthritis (RA), however, its efficacy is quite weak. In the present study, a library of novel sinomenine-based homodimers and monomers through variable-length linkers were designed and synthesized, and their bioactivities
Yi Hong et al.
Cancer immunology, immunotherapy : CII, 62(3), 447-454 (2012-09-04)
Transferrin receptor (TfR) has been used as a target for the antibody-based therapy of cancer due to its higher expression in tumors relative to normal tissues. Great potential has been shown by anti-TfR antibodies combined with chemotherapeutic drugs as a
Mei-Yu Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(4), 597-604 (2013-05-30)
To observe the analgesic effect of sinomenine on the neuropathic pain rat model induced by SSNI, and discuss its impact on monoamine neurotransmitters in striatal extracellular fluid. Male SD rats were randomly divided into the sham operation group, the SSNI
Y C Oh et al.
European review for medical and pharmacological sciences, 16(9), 1184-1191 (2012-10-11)
Sinomenine is an alkaloid compound and a prominent anti-inflammatory agent found in the root of the climbing plant Sinomenium acutum. However, its effects on the mechanism of human mast cell line (HMC)-1-mediated inflammation remained unknown. To provide insight into the
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