About This Item
Fórmula linear:
C6H5CONHCH3
Número CAS:
Peso molecular:
135.16
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de substância PubChem:
NACRES:
NA.22
Produtos recomendados
Ensaio
≥99%
forma
solid
pb
167 °C/11 mmHg (lit.)
pf
76-78 °C (lit.)
solubilidade
ethanol: soluble 50 mg/mL, clear, yellow-green
cadeia de caracteres SMILES
CNC(=O)c1ccccc1
InChI
1S/C8H9NO/c1-9-8(10)7-5-3-2-4-6-7/h2-6H,1H3,(H,9,10)
chave InChI
NCCHARWOCKOHIH-UHFFFAOYSA-N
Descrição geral
N-Methylbenzamide is a potent PDE10A (phosphodiesterase with a remarkable localization as the protein is abundant only in brain tissue) inhibitor.
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John Paul Kilburn et al.
Bioorganic & medicinal chemistry, 21(19), 6053-6062 (2013-08-28)
PDE10A is a recently identified phosphodiesterase with a quite remarkable localization since the protein is abundant only in brain tissue. Based on this unique localization, research has focused extensively on using PDE10A modulators as a novel therapeutic approach for dysfunction
H van de Waterbeemd et al.
Journal of medicinal chemistry, 29(5), 600-606 (1986-05-01)
The electronic properties of orthopramides, a group of selective D-2 dopamine receptor antagonists, were investigated by calculating molecular electrostatic potentials (MEP) of model compounds with the ab initio STO-3G MO method. The various substitution patterns of the aromatic ring are
Atsushi Satoh et al.
Bioorganic & medicinal chemistry letters, 19(18), 5464-5468 (2009-08-14)
We identified 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide 27 as a potent mGluR1 antagonist. The compound possessed excellent subtype selectivity and good PK profile in rats. It also demonstrated relatively potent antipsychotic-like effects in several animal models. Suitable for development as a PET tracer, compound
L Constantino et al.
Biochemical pharmacology, 44(4), 651-658 (1992-08-18)
The metabolism of N,N-dimethylbenzamides by phenobarbital-induced rat liver microsomes results in the formation of N-methylbenzamides and formaldehyde. The reaction proceeds via the formation of an intermediate N-hydroxymethyl-N-methylbenzamide, which, for the microsomal oxidation of N,N-dimethylbenzamide, was isolated and characterized. Confirmation of
Shih-Chung Huang et al.
Bioorganic & medicinal chemistry letters, 14(18), 4779-4782 (2004-08-25)
A series of N-methylbenzamide analogues (2-18) that is structurally derived from SR 48,968, a potent neurokinin-2 (NK(2)) receptor antagonist (pK(b)9.1), has been obtained using asymmetric synthesis. Isothiocyanato-N-methylbenzamide (10-12) and bromoacetamido-N-methylbenzamide derivatives (16-18) have been designed to serve as potential electrophilic
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