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Sigma-Aldrich

Hydroxypropyl cellulose

average Mw ~100,000, powder, 20 mesh particle size (99% through)

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About This Item

Número CAS:
9004-64-2
Número MDL:
MFCD00132688
Código UNSPSC:
12162002
NACRES:
NA.23

descrição

biological oxygen demand (BOD) 14,000 ppm

forma

powder

temperatura de autoignição

752 °F

peso molecular

average Mw ~100,000

Impurezas

<5 wt. %

tamanho de partícula

20 mesh (99% through)

pH

5.0-8.5

tensão interfacial do óleo mineral

12.5 dyn/cm, 0.1 wt. % in H2O (vs. mineral oil)

viscosidade

65-175 cP, 5 wt. % in H2O(25 °C, Brookfield, spindle #1) (30 rpm)(lit.)

solubilidade

polar organic solvents: soluble

densidade

0.5 g/mL at 25 °C (lit.)

InChI

1S/C12H20N2/c1-5-12(13)11-7-6-10(14(3)4)8-9(11)2/h6-8,12H,5,13H2,1-4H3

chave InChI

RRHXDYJWVYFMKV-UHFFFAOYSA-N

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Descrição geral

Hydroxypropyl cellulose (HPC) is a neutral polysaccharide prepared by reacting propylene oxide with alkali cellulose at high temperatures and pressure. It is soluble in water and many polar organic solvents. HPC is widely used as a food additive and in drug delivery systems.

Aplicação

Hydroxypropyl cellulose can be used in the following applications:
  • HPC is soluble in organic solvents which makes it suitable for the preparation of polymer gel electrolytes for electrochemical devices. The network-forming ability of HPC can improve the mechanical and electrical properties of gel electrolytes.
  • Electrospun hydroxypropyl cellulose nanofibres can be used to develop drug delivery systems for a variety of hydrophobic drugs.
  • Hydroxypropylcellulose combined with an effervescent agent like sodium carbonate can be usedas a binder and functional material to prepare floating tablets for thecontrolled release of ofloxacin.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Xiaole Qi et al.
International journal of pharmaceutics, 489(1-2), 210-217 (2015-05-10)
To prolong the residence time of dosage forms within gastrointestinal trace until all drug released at desired rate was one of the real challenges for oral controlled-release drug delivery system. Herein, we developed a fine floating tablet via compression coating
Jeremiah F Kelleher et al.
AAPS PharmSciTech, 21(1), 23-23 (2019-12-14)
The development of oral solid dosage forms, such as tablets that contain a high dose of drug(s), requires polymers and other additives to be incorporated at low levels as possible, to keep the final tablet weight low, and, correspondingly, the
Daniela M Correia et al.
Materials (Basel, Switzerland), 13(10) (2020-05-21)
This study reports a versatile method for the development of cellulose nanocrystals (CNCs) and water-soluble cellulose derivatives (methyl cellulose (MC), hydroxypropyl cellulose (HPC), and sodium carboxymethyl cellulose (NaCMC)) films comprising the ionic liquid (IL) 2-hydroxy-ethyl-trimethylammonium dihydrogen phosphate ([Ch][DHP]) for actuator
Catherine Boissier et al.
Journal of pharmaceutical sciences, 101(7), 2512-2522 (2012-04-28)
Nuclear magnetic resonance (NMR) cryoporometry and scanning electron microscopy (SEM) image analysis have been used to investigate the size and shape distribution of pores in pharmaceutical coatings. The coatings were made from a mixture of hydroxypropylcellulose (HPC) and ethylcellulose (EC).
Homendra Naorem et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 101, 67-73 (2012-10-27)
The formation constant of triiodide ions from iodine-iodide equilibrium in aqueous-organic solvent or polymer mixed media have been determined spectrophotometrically at three different temperatures 20, 30 and 40°C. The organic solvents chosen for the study are ethylene glycol, 2-methoxy ethanol
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