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4′-(Imidazol-1-yl)acetophenone

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R$ 928,00

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5 G
R$ 928,00

About This Item

Fórmula empírica (Notação de Hill):
C11H10N2O
Número CAS:
Peso molecular:
186.21
Número CE:
Número MDL:
Código UNSPSC:
12352005
ID de substância PubChem:
NACRES:
NA.22

R$ 928,00


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Nível de qualidade

Ensaio

96%

Formulário

solid

pf

108-110 °C (lit.)

grupo funcional

ketone

cadeia de caracteres SMILES

CC(=O)c1ccc(cc1)-n2ccnc2

InChI

1S/C11H10N2O/c1-9(14)10-2-4-11(5-3-10)13-7-6-12-8-13/h2-8H,1H3

chave InChI

GAIQQJIMVVUTQN-UHFFFAOYSA-N

Descrição geral

4′-(Imidazol-1-yl)acetophenone is a selective thromboxane synthesis inhibitor[1].

Aplicação

4′-(Imidazol-1-yl)acetophenone was used in the synthesis of (R)-(+)-4′-(imidozol-1-yl)-phenyl ethanol using spiroborate catalyst[2].

Pictogramas

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Palavra indicadora

Warning

Frases de perigo

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves


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Viatcheslav Stepanenko et al.
Tetrahedron, asymmetry, 18(23), 2738-2745 (2007-11-26)
The effectiveness of several spiroborate ester catalysts was investigated in the asymmetric borane reduction of 2-, 3-, 4-acetylpyridines under different reaction conditions. Highly enantiomerically enriched 1-(2-, 3- and 4-pyridyl)ethanols and 1-(heterocyclic)ethanols were obtained using 1 to 10% catalytic loads of
H D Uderman et al.
Prostaglandins, 24(2), 237-244 (1982-08-01)
The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted blood) were suppressed by 89.1% (p less than 0.001) and 41.2% (p less than 0.01) at
A J Watson et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 8(1), 26-30 (1986-07-01)
It has recently been postulated that thromboxane A2 may participate in the pathogenesis of acute myohemoglobinuric experimental acute renal failure. To investigate this further, the effect of selective inhibition of thromboxane synthesis on the course of glycerol-induced acute renal failure
J Triscari et al.
International journal of obesity, 11 Suppl 3, 43-51 (1987-01-01)
A selective inhibitor of thromboxane synthase, Ro 22-3581 has been shown to be a useful tool for investigating the relationship between hyperinsulinemia and obesity. These studies have established that the pharmacologic normalization of the hyperinsulinemia associated with elevated weights in
P A Craven et al.
The Journal of laboratory and clinical medicine, 116(4), 469-478 (1990-10-01)
Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we examined urinary albumin, protein, and thromboxane B2 (TXB2) excretion during

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