SHH
sonic hedgehog
Sinônimos:
HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
Espécies:
Human SHH (6469), Mouse Shh (20423), Rat Shh (29499), chicken SHH (395615), domestic cat SHH (100169727), dog SHH (608860), sheep SHH (101117666), sheep SHH (780492), cow SHH (286821), Domestic Rabbit SHH (100352774) ...Mais
ID UniProtKB:
ID do gene:
- Human(6469) Summary: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
- Mouse(20423) sonic hedgehog
- Rat(29499) sonic hedgehog
- chicken(395615) sonic hedgehog
- domestic cat(100169727) sonic hedgehog
- dog(608860) sonic hedgehog
- sheep(101117666) sonic hedgehog
- sheep(780492) sonic hedgehog
- cow(286821) sonic hedgehog
- Domestic Rabbit(100352774) sonic hedgehog
- domestic guinea pig(100732014) sonic hedgehog
- naked mole-rat(101719896) sonic hedgehog
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ELISA
Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Sonic Hedgehog/Shh Antibody, clone 5E1, ,
Reatividade de espécies
chicken, human, mouse, rat
Aplicação
electron microscopy
immunocytochemistry
immunofluorescence
immunohistochemistry
inhibition assay
western blot
immunocytochemistry
immunofluorescence
immunohistochemistry
inhibition assay
western blot
Anti-SHH Antibody, clone 5H4, clone 5H4, from mouse,
Reatividade de espécies
human, monkey, mouse
Aplicação
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Sonic Hedgehog Antibody, from rabbit, purified by affinity chromatography,
Reatividade de espécies
human, mouse
Aplicação
immunohistochemistry
western blot
western blot
Anti-SHH, affinity isolated antibody,
Reatividade de espécies
dog, guinea pig, horse, human, mouse, rabbit, rat
Aplicação
immunohistochemistry
western blot
western blot
Anti-Sonic Hedgehog (Shh) antibody produced in rabbit, ,
Reatividade de espécies
human, mouse, rat
Aplicação
immunohistochemistry
western blot
western blot
Proteins
Número do produto
Descrição
Espécies
Sonic Hedgehog human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Espécies
human
Sonic Hedgehog Peptide from mouse, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder,
Espécies
mouse