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Merck

KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

Sinônimos:
KIR1.1, ROMK, ROMK1
Espécies:
ID UniProtKB:
ID do gene:
  • Human(3758) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56379) potassium inwardly-rectifying channel, subfamily J, member 1
  • Rat(24521) potassium inwardly-rectifying channel, subfamily J, member 1
  • chicken(428236) potassium inwardly-rectifying channel, subfamily J, member 1
  • Horse(100072580) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic cat(101091140) potassium inwardly-rectifying channel, subfamily J, member 1
  • cow(539250) potassium inwardly-rectifying channel, subfamily J, member 1
  • dog(489285) potassium inwardly-rectifying channel, subfamily J, member 1
  • naked mole-rat(101720253) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic guinea pig(100722828) potassium inwardly-rectifying channel, subfamily J, member 1

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Small Molecule - Activator

Número do produto
Descrição
Espécies
Diazoxide, ,
Espécies
rat, mouse, human

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
Cromakalim, ,
Espécies
rat
Glyburide, meets USP testing specifications,
Espécies
rat, human
Glybenclamide, ≥99% (HPLC),
Espécies
rat, human
Chlorpropamide, analytical standard, ≥97%,
Espécies
human, mouse
Tolbutamide, analytical standard,
Espécies
human, mouse

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-KCNJ1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
Anti-KCNJ1 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
dog, guinea pig, horse, human, rabbit, rat
Aplicação
western blot
Anti-ROMK antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunofluorescence
Anti-KCNJ1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
western blot

Small Molecule - Blocker

Número do produto
Descrição
Espécies
Gliclazide, powder, ≥98%,
Espécies
human
Glimepiride, ≥98% (HPLC), solid,
Espécies
human
Repaglinide, ≥98% (HPLC), solid,
Espécies
human
Glipizide, solid,
Espécies
human
Glyburide, meets USP testing specifications,
Espécies
rat, human

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Linopirdine, ≥98% (HPLC),
Espécies
rat
VU591, ≥98% (HPLC),
Espécies
human
Tertiapin-Q trifluoroacetate salt, ≥97% (HPLC),
Espécies
rat, human, mouse
Chlorpropamide, analytical standard, ≥97%,
Espécies
human, mouse
Tolbutamide, analytical standard,
Espécies
human, mouse

Small Molecule - Ligand

Número do produto
Descrição
Espécies
Glimepiride, ≥98% (HPLC), solid,
Espécies
human
Glipizide, solid,
Espécies
human
Glybenclamide, ≥99% (HPLC),
Espécies
rat, human
Chlorpropamide, analytical standard, ≥97%,
Espécies
human, mouse

Small Molecule - Opener

Número do produto
Descrição
Espécies
Minoxidil, ≥99% (TLC),
Espécies
human
Diazoxide, ,
Espécies
rat, mouse, human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human KCNJ1,
Espécies
human