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Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Sinônimos:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Espécies:
ID UniProtKB:
ID do gene:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2

Custom & Knockdown Gene Products

Small Molecule - Agonist

Número do produto
Descrição
Espécies
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Espécies
human
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Espécies
human
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Espécies
human
(±)-Baclofen, ≥98% (HPLC), solid,
Espécies
human, rat
γ-Aminobutyric acid, ≥99%,
Espécies
human, rat

Small Molecule - Allosteric Modulator

Número do produto
Descrição
Espécies
CGP-13501, ≥98% (HPLC), solid,
Espécies
human

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
2-Hydroxysaclofen, ≥98% (TLC), solid,
Espécies
human
Phaclofen, solid,
Espécies
human
(±)-Baclofen, ≥98% (HPLC), solid,
Espécies
human, rat
Saclofen, solid,
Espécies
mouse, human, rat
γ-Aminobutyric acid, ≥99%,
Espécies
human, rat

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti GABBR2 Antibody, clone 23GB5500, Rabbit Monoclonal, clone 23GB5500, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reatividade de espécies
human, rat
Aplicação
western blot
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
Reatividade de espécies
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Aplicação
immunohistochemistry
western blot
Anti-GABAB Receptor 2 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reatividade de espécies
rat
Aplicação
western blot
Monoclonal Anti-Gaba-B Receptor 2 - Rpe antibody produced in mouse, clone S81-2, purified immunoglobulin,
Reatividade de espécies
human, mouse, rat
Aplicação
immunocytochemistry
immunohistochemistry

western blot
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
NO-711 hydrochloride, ≥98% (HPLC),
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human GABBR2,
Espécies
human