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T8637

Sigma-Aldrich

Chlorure de thiamine monophosphate dihydrate

Synonyme(s) :

Chlorure d’aneurine monophosphate

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About This Item

Formule empirique (notation de Hill):
C12H18ClN4O4PS · 2H2O
Numéro CAS:
273724-21-3
Poids moléculaire :
416.82
Numéro Beilstein :
3844977
Numéro CE :
208-536-9
Numéro MDL:
MFCD00063473
Code UNSPSC :
12352107
ID de substance PubChem :
24900546
Nomenclature NACRES :
NA.79

Source biologique

synthetic

Pureté

≥99.0% (HPLC)

Forme

powder

Technique(s)

HPLC: suitable

Couleur

white to off-white

Pf

190 °C

Température de stockage

2-8°C

Chaîne SMILES 

[Cl-].Cc1ncc(C[n+]2csc(CCOP(O)(O)=O)c2C)c(N)n1

InChI

1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H

Clé InChI

GUGWNSHJDUEHNJ-UHFFFAOYSA-N

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Application

Thiamine monophosphate chloride dihydrate has been used as a standard in high-performance liquid chromatography (HPLC) to quantify thiamine in plant exudates and to evaluate its purity.

Actions biochimiques/physiologiques

Thiamine monophosphate (TMP) is used as a substrate of thiamine-phosphate kinase (EC 2.7.4.16) and a precursor of thiamine pyrophosphate (TPP). TPP is a coenzyme involved in the catabolism of sugars and amino acids.
Thiamine monophosphate (TMP) is used as a substrate of thiamine-phosphate kinase (EC 2.7.4.16) and a precursor of thiamine pyrophosphate (TPP). TPP is a coenzyme involved in the catabolism of sugars and amino acids. TMP acts as an intermediate in the hydrolysis of thiamine pyrophosphate to thiamine.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

M Héroux et al.
Neurochemical research, 20(1), 87-93 (1995-01-01)
Thiamine phosphate esters (thiamine monophosphate-TMP; thiamine diphosphate-TDP and thiamine triphosphate-TTP) were measured as their thiochrome derivatives by High Performance Liquid Chromatography in the brains of pyrithiamine-treated rats at various stages during the development of thiamine deficiency encephalopathy. Severe encephalopathy was
M Héroux et al.
Metabolic brain disease, 11(1), 81-88 (1996-03-01)
There is a growing body of evidence to suggest that thiamine neurochemistry is disrupted in Alzheimer's Disease (AD). Studies in autopsied brain tissue from neuropathologically proven AD patients reveal significantly reduced activities of the thiamine phosphate dephosphorylating enzymes thiamine diphosphatase
New Research and Developments of Water-Soluble Vitamins (2018)
Carsten Wrenger et al.
Biological chemistry, 387(1), 41-51 (2006-02-25)
Vitamin B1 (thiamine) is an essential cofactor for several key enzymes of carbohydrate metabolism. Mammals have to salvage this crucial nutrient from their diet to complement their deficiency of de novo synthesis. In contrast, bacteria, fungi, plants and, as reported
Maria Rapala-Kozik et al.
Plant physiology and biochemistry : PPB, 47(4), 237-242 (2009-01-27)
The pool of thiamine diphosphate (TDP), available for TDP-dependent enzymes involved in the major carbohydrate metabolic pathways, is controlled by two enzyme systems that act in the opposite directions. The thiamine pyrophosphokinase (TPK) activates thiamine into TDP and the numerous
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