Histone H3 peptide mono-methylated at Lysine 9, biotinylated, substrate for histone demethylases belonging to the Jumanji domain-containing (JMJ) family .
Application
Suitable as a substrate for histone demethylases belonging to the Jumonji (JMJ) family. It can be used to study enzyme kinetics, and to screen small molecular inhibitors of these demethylases for drug discovery and HTS applications.
Autres remarques
500 μL at 40 μM, or 20 nmol Sold as 500 μL
Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Current opinion in cell biology, 16(3), 230-238 (2004-05-18)
Heterochromatin mediates various nuclear processes including centromere function, gene silencing and nuclear organization. Although it was discovered nearly 75 years ago, the pathways involved in heterochromatin establishment, assembly and epigenetic maintenance have been elusive. Recent reports have demonstrated that distinct
The functional significance of mono-, di-, and trimethylation of lysine residues within histone proteins remains unclear. Antibodies developed to selectively recognize each of these methylated states at histone H3 lysine 9 (H3 Lys9) demonstrated that mono- and dimethylation localized specifically
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