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SML1376

Sigma-Aldrich

BTC

≥95% (HPLC)

Synonyme(s) :

2-(4-Hydroxyphenyl)-1-benzothiophene-6-ol, 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol

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About This Item

Formule empirique (notation de Hill):
C14H10O2S
Numéro CAS:
63676-22-2
Poids moléculaire :
242.29
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77

Pureté

≥95% (HPLC)

Forme

powder

Conditions de stockage

protect from light

Couleur

white to light brown

Solubilité

DMSO: 20 mg/mL, clear

Température de stockage

−20°C

InChI

1S/C14H10O2S/c15-11-4-1-9(2-5-11)13-7-10-3-6-12(16)8-14(10)17-13/h1-8,15-16H

Clé InChI

MDGWZLQPNOETLH-UHFFFAOYSA-N

Actions biochimiques/physiologiques

BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM). BTC has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα), which is often associated with tamoxifen resistance. BTC caused regression of endocrine-resistant breast cancer xenografts, and did not support the growth of hormone-dependent xenografts in vivo or cause an increase in uterine weight. As in the case with raloxifene and estradiol, BTC tumor regression was accompanied by the exit of ERα from the nucleus, suggesting extranuclear ERα may be involved in the mehanism of action.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Fuping Li et al.
Small (Weinheim an der Bergstrasse, Germany), 16(14), e1906276-e1906276 (2020-03-05)
Direct conversion of syngas to dimethyl ether (DME) through the intermediate of methanol allows more efficient DME production in a simpler reactor design relative to the conventional indirect route. Although Cu/ZnO-based multicomponent catalysts are highly active for methanol synthesis in
Rui Pei et al.
Journal of hazardous materials, 384, 121418-121418 (2019-12-11)
Three-dimensional (3D) printing technique has received exceptional global attention as it can create a myriad of high-resolution architectures from digital models. In the present study, 3D-printed metal-organic frameworks (MOFs) were shaped into several geometries via direct ink writing, which overcomes
Axel X Canatelli et al.
ChemPlusChem, 85(10), 2349-2356 (2020-10-24)
Metal-organic frameworks (MOFs) are known for their versatility in terms of their crystalline structure, porosity, resistance to temperature, radiation damage, and luminescence among others. Gadolinium (Gd) is one of the elements with the highest reported cross-section for low energy neutron
Jibin An et al.
Environmental research, 191, 110067-110067 (2020-08-21)
Metal-organic frameworks (MOFs) are emerging class of porous materials that attracted tremendous attention as eco-friendly photocatalysts. However, poor charge separation in most MOFs largely thwarts their photocatalytic performance. In this work, Materials of Institut Lavoisier-100(Fe) (MIL-100 (Fe)) based on iron
Ho-Young Jang et al.
Environmental pollution (Barking, Essex : 1987), 267, 115583-115583 (2020-12-02)
In this study, a metal organic framework MIL-100(Fe) was synthesized for rhodamine B (RB) removal from aqueous solutions. An experimental design was conducted using a central composite design (CCD) method to obtain the RB adsorption data (n = 30) from batch experiments.
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