SML0683

JNJ-40418677

≥98% (HPLC)

• Synonyme(s) : 2-(S)-(3,5-Bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid
• Formule empirique (notation de Hill): C₂₆H₂₂F₆O₂
• Numéro CAS: 1146594-87-7
• Poids moléculaire : 480.44
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL, clear
• Auteur: Johnson & Johnson
• Maladie(s) pertinente(s): Alzheimer′s disease
• Température de stockage: 2-8°C

Description

Actions biochimiques/physiologiques

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC₅₀ = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300,H413
• Conseils de prudence: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 2 Oral - Aquatic Chronic 4
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable