SMB01018

Cynaropicrin

≥90% (LC/MS-ELSD)

• Formule empirique (notation de Hill): C₁₉H₂₂O₆
• Numéro CAS: 35730-78-0
• Poids moléculaire : 346.37
• Numéro MDL: MFCD31614147
• Code UNSPSC : 12352205
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant
• Essai: ≥90% (LC/MS-ELSD)
• Forme: solid
• Poids mol.: 346.37
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: −20°C
• Chaîne SMILES: O1[C@@H]2[C@@H]3[C@@H](C[C@@H](C3=C)O)C(=C)C[C@@H]([C@H]2C(=C)C1=O)OC(=O)C(=C)CO
• InChI: 1S/C19H22O6/c1-8-5-14(24-18(22)9(2)7-20)16-11(4)19(23)25-17(16)15-10(3)13(21)6-12(8)15/h12-17,20-21H,1-7H2/t12-,13-,14-,15-,16+,17+/m0/s1
• Clé InChI: KHSCYOFDKADJDJ-NQLMQOPMSA-N

Description

Description générale

Cynaropicrin is a sesquiterpene lactone, a bioactive natural compound commonly derived from plants such as Cynara scolymus, Pleiotaxis rugosa, Pseudostifftia kingii, Blumea eriantha, and Scopolia atropoides. Current research indicates that this plant metabolite is an inhibitor and may possess diverse biological activities, including anti-inflammatory, antineoplastic, antispasmodic, anti-hyperlipidemic, anti-trypanosomal, anti-malarial, and antiviral properties.

Application

Cynaropicrin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Actions biochimiques/physiologiques

Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, making it a potential candidate for preventing UVB-induced photoaging. Additionally, it exhibits pro-apoptotic activity, suggesting its potential as an anticancer agent against certain leukocyte cancer cells such as lymphoma or leukemia. Cynaropicrin has demonstrated in vivo activity against Trypanosoma brucei and exhibits immunomodulatory effects by influencing cytokine release and nitric oxide production while also displaying immunosuppressive properties. Moreover, it has anti-inflammatory effects by inhibiting the production of inflammatory mediators and lymphocyte proliferation, which is achieved through conjugation with sulphydryl groups of target protein(s).

Caractéristiques et avantages

• Suitable for Biochemical and Biomedical research
• Versatile and adaptable for wide variety of laboratory and research applications

Autres remarques

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable