E6657

Eplerenone

≥98% (HPLC)

• Synonyme(s) : 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110
• Formule empirique (notation de Hill): C₂₄H₃₀O₆
• Numéro CAS: 107724-20-9
• Poids moléculaire : 414.49
• Numéro MDL: MFCD05662207
• Code UNSPSC : 51111800
• ID de substance PubChem : 329798999
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear (warmed); H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C
• InChI: 1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
• Clé InChI: JUKPWJGBANNWMW-VWBFHTRKSA-N
• Informations sur le gène: human ... NR3C2(4306)

Description

Description générale

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction.[1] Eplerenone is used for treating hypertension and central serous retinopathy.[2][3] It exhibits potassium sparing diuretic effect.[4]

Application

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.[5]

Actions biochimiques/physiologiques

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)