S0569

SB 239063

>98% (HPLC)

• Synonyme(s) : trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole
• Formule empirique (notation de Hill): C₂₀H₂₁N₄O₂F
• Numéro CAS: 193551-21-2
• Poids moléculaire : 368.40
• Numéro MDL: MFCD03792786
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824431
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: >98% (HPLC)
• Forme: powder
• Couleur: white
• Pf: 206-207.2 °C
• Solubilité: DMSO: 11 mg/mL; H₂O: insoluble
• Auteur: GlaxoSmithKline
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1nccc(n1)-c2c(ncn2[C@@H]3CC[C@@H](O)CC3)-c4ccc(F)cc4
• InChI: 1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16-
• Clé InChI: ZQUSFAUAYSEREK-WKILWMFISA-N

Description

Description générale

SB 239063 helps to decrease neutrophilia, inflammatory cytokines, matrix metallopeptidase 9 (MMP-9) and fibrosis in the lung.

Application

SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38 MAP kinase, and extracellular signal regulated protein kinase (ERK)/p42/p44 mitogen activated protein kinase (MAPK) on the viability and apoptosis of cardiomyocytes under glutathione S-transferase (GST) inhibition. It has also been used in neuron-microglia conditioned media (CM) experiments and pharmacokinetics.

Actions biochimiques/physiologiques

Potent p38 MAP kinase inhibitor. Selective for α and β. No activity against γ and δ isoforms.

Caractéristiques et avantages

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

Sold for research purposes under agreement from Glaxo­Smith­Kline

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)