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P3591

Sigma-Aldrich

1,2-Dioctanoyl-sn-glycerol 3-phosphate sodium salt

≥99%

Synonyme(s) :

L-α-Phosphatidic acid, dioctanoyl sodium salt

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About This Item

Formule linéaire :
C19H36O8PNa
Numéro CAS:
178603-80-0
Poids moléculaire :
446.45
Numéro MDL:
MFCD00679111
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Pureté

≥99%

Forme

powder

Température de stockage

−20°C

InChI

1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1

Clé InChI

ZNDNSOYDPUTHKQ-UNTBIKODSA-M

Description générale

1,2-Dioctanoyl-sn-glycerol 3-phosphate sodium salt is a cell-permeable phosphatidic acid (PA).

Application

1,2-Dioctanoyl-sn-glycerol 3-phosphate sodium salt has been used:
  • to study its effects on neural stem/precursor cell (NSC) proliferation
  • to study the effects of phosphatidic acid (PA) on actin filament dynamics in Arabidopsis thaliana epidermal leaf cells
  • to treat vector-transfected cells and to verify the attenuation of hypoxia-inducible factor-1α (HIF-1α) induction in phospholipase D (PLD)-transfected cells by butanol

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

Jindřiška Matoušková et al.
Plant science : an international journal of experimental plant biology, 223, 36-44 (2014-04-29)
Changes in actin cytoskeleton dynamics are one of the crucial players in many physiological as well as non-physiological processes in plant cells. Positioning of actin filament arrays is necessary for successful establishment of primary lines of defense toward pathogen attack
Yuko Fujita et al.
Biochemical and biophysical research communications, 370(1), 169-173 (2008-03-25)
While a mother's excessive alcohol consumption during pregnancy is known to have adverse effects on fetal neural development, little is known about the underlying mechanism of these effects. In order to investigate these mechanisms, we investigated the toxic effect of
ETOH inhibits embryonic neural stem/precursor cell proliferation via PLD signaling
Fujita Y, et al.
Biochemical and Biophysical Research Communications, 370(1), 169-173 (2008)
Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
Han S, et al.
Experimental & Molecular Medicine, 46(12), e126-e126 (2014)
Songyi Han et al.
Experimental & molecular medicine, 46, e126-e126 (2014-12-20)
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is believed to play an important role in tumorigenesis. In this
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