Product H7779, Retinoic acid p-hydroxyanilide, can be dissolved in DMSO (25 mg/ml) and ethanol (25 mg/ml).
H7779
Retinoic acid p-hydroxyanilide
≥95%
Synonyme(s) :
4-HPR, Fenretinide, N-(4-Hydroxyphenyl)retinamide
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5 MG
176,00 €
176,00 €
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5 MG
176,00 €
About This Item
Formule empirique (notation de Hill) :
C26H33NO2
Numéro CAS:
Poids moléculaire :
391.55
Numéro MDL:
Code UNSPSC :
12352106
ID de substance PubChem :
Nomenclature NACRES :
NA.77
176,00 €
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Devis pour commande en gros
Produits recommandés
Source biologique
synthetic (organic)
Essai
≥95%
Forme
powder
Couleur
yellow to yellow-orange
Température de stockage
−20°C
Chaîne SMILES
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(=O)Nc2ccc(O)cc2)C(C)(C)CCC1
InChI
1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
Clé InChI
AKJHMTWEGVYYSE-FXILSDISSA-N
Catégories apparentées
Description générale
Retinoic acid p-hydroxyanilide is a synthetic analog of retinoid.[1]
Application
Actions biochimiques/physiologiques
Retinoic acid p-hydroxyanilide, also called fenretinide, increases reactive oxygen species, activates caspases and induces apoptosis.[1] It also inhibits dihydroceramide desaturase, leading to a decrease in ceramide biosynthesis.[2] Fenretinide may elicit anticancer activity in cultured human breast cancer cells.[2] It acts as an insulin antagonist and may be useful in treating insulin resistance.[2] Fenretinide or 4-HPR has chemotherapeutic potential and is cytotoxic to retinoic acid-resistant cancers.[3]
Vitamin A acid analogue with antiproliferative activity; induces apoptosis in malignant hemopoietic cell lines.
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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The synthetic retinoid 4-hydroxyphenylretinamide (HPR) showed antiproliferative effect on cultured human breast cancer cells, which were sensitive to retinoic acid (RA) too. Investigation of the cell cycle by flow cytophotometry showed a significant increase of cells in the S-phase of
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In what solvents can product H7779, Retinoic acid p-hydroxyanilide, be dissolved?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How can one store a solution of product H7779, Retinoic acid p-hydroxyanilide?
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A solution of product H7779, Retinoic acid p-hydroxyanilide, can be aliquoted and stored at -20°C for up to 3 months. Solutions should be protect from light.
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