GEE70092Z
Shrimp Alkaline Phosphatase
Cytiva E70092Z, pack of 1000 U
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About This Item
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54
214,00 €
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Produits recommandés
Forme
solid
Conditionnement
pack of 1000 U
Fabricant/nom de marque
Cytiva E70092Z
Conditions d'expédition
dry ice
Température de stockage
−20°C
Catégories apparentées
Description générale
Shrimp alkaline phosphatase is a high specific activity, heat-labile alkaline phosphatase. Completely and irreversibly inactivated in Tris buffers at pH 8.0 to 8.5 by heating for 15 min at 65°C. No further treatment is necessary. The ALP (alkaline phosphatase) gene codes for a membrane-bound ectoenzymes that is present in four isoforms and is distributed as tissue nonspecific, intestinal, placenta, and germ cell ALP.[1] The tissue nonspecific enzyme is ubiquitously expressed in a variety of tissues including liver, bone, kidney and is predominant in osteoblasts.[2][1] Alkaline phosphatase is also known as mesenchymal stem cell antigen 1 or tissue nonspecific alkaline phosphatase.[2]
Actions biochimiques/physiologiques
Alkaline phosphatase hydrolyses pyrophosphate (PPi) to inorganic phosphate and thus maintains a balance between the two forms of phosphate which is highly essential for mineralization.[3][1] Higher levels of serum alkaline phosphatase is found in prostate cancer.[2] Severe TNAP deficiency refers to hypophosphatasia characterized with defective pyridoxal 5′-phosphate metabolism and skeletal hypomineralization.[1]
Caractéristiques et avantages
- Removing 5′-phosphates from DNA and RNA.
- Easily inactivated by heat.
Stockage et stabilité
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
Remarque sur l'analyse
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
Code de la classe de stockage
12 - Non Combustible Liquids
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Certificats d'analyse (COA)
Lot/Batch Number
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Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer.
Rao S R, et al.
British Journal of Cancer, 116(2), 227-227 (2017)
The mechanism of mineralization and the role of alkaline phosphatase in health and disease.
Orimo H
Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi, 77(1), 4-12 (2010)
Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC.
Jin H, et al.
Science Signaling, 9(458), ra121-ra121 (2016)
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