C0984

Creatine Kinase MB Fraction from human heart

≥70% (SDS-PAGE), liquid

• Synonyme(s) : CK MB Fraction
• Numéro MDL: MFCD00151686
• Code UNSPSC : 12352204
• Nomenclature NACRES : NA.54

Propriétés

• Source biologique: human heart
• Niveau de qualité: 200
• Essai: ≥70% (SDS-PAGE)
• Forme: liquid
• Concentration: ≥0.5 mg/mL
• Technique(s): IR spectroscopy: suitable
• Adéquation: suitable for tissue
• Numéro d'accès UniProt: P06732; P12277
• Application(s): pharmaceutical
• Température de stockage: −20°C
• Informations sur le gène: human ... CKB(1152) , CKM(1158)

Description

Description générale

Research area: Cell Signaling
Creatine Kinase (CK) comprises M and B subunit and is a dimeric molecule. It is one among the isoenzymes of CK. The enzyme is majorly present in the myocardium.[1]

Application

Creatine Kinase MB Fraction from human heart has been used:

• as a diagnostic marker for acute myocardial infarction.[2]
• to identify overlapping absorbance peaks between blood and the cardiac biomarkers.[3]
• to study the phosphorylation pathway of dioxolane guanosine (DXG) in vivo, a potential treatment of HIV-1 infection.[4]

Actions biochimiques/physiologiques

Creatine Kinase (CK) catalyzes the formation of creatinine from creatine phosphate.[1] The enzyme is associated with coronary performance. Elevated serum levels of CK-MB are prime indicators of myocardial cellular injury.[1] It is regarded as a “gold standard” for myocardial infarction diagnosis.[1] The levels of cardiac troponin I (cTnI) or cardiac troponin T also correlate to higher CK-MB) levels.[5] CK-MB levels may also be elevated in chronic renal failure.[6]

Composants

Solution in 5 mM sodium succinate, 10 mM sodium chloride, 1 mM EDTA, 5 mM β-mercaptoethanol, 50% glycerol, pH 7.0.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable