A1076

BAPTA-AM

≥95% (HPLC), powder, intracellular Ca²⁺ store chelator

• Synonyme(s) : 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)
• Formule empirique (notation de Hill): C₃₄H₄₀N₂O₁₈
• Numéro CAS: 126150-97-8
• Poids moléculaire : 764.68
• Numéro Beilstein : 7458534
• Numéro MDL: MFCD00036696
• Code UNSPSC : 12352200
• ID de substance PubChem : 24890502
• Nomenclature NACRES : NA.77

Propriétés

• product name: BAPTA-AM, ≥95% (HPLC)
• Pureté: ≥95% (HPLC)
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccccc1OCCOc2ccccc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O
• InChI: 1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
• Clé InChI: YJIYWYAMZFVECX-UHFFFAOYSA-N

Description

Description générale

BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca²⁺-activated K⁺ channel currents. BAPTA-AM maintains intracellular Ca²⁺ homeostasis.

Application

BAPTA-AM has been used :

• to reduce the elevation of cleaved caspase-3
• to block cell death, inhibit ROS (reactive oxygen species) production and inhibit caspase-8 activation
• to exclude the effect of changes in intracellular Ca²⁺ ([Ca²⁺]_i) concentration during seizure induction
• to eliminate the increase of [Ca²⁺]_i induced by 6-hydroxydopamine (6-OHDA)

Actions biochimiques/physiologiques

Selective chelator of intracellular Ca²⁺ stores.

Liaison

Membrane-permeable form of BAPTA.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves