A0760

L-Azetidine-2-carboxylic acid

≥99%

• Synonyme(s) : (S)-Azetidine-2-carboxylic acid
• Formule empirique (notation de Hill) : C₄H₇NO₂
• Numéro CAS: 2133-34-8
• Poids moléculaire : 101.10
• Beilstein: 80680
• Numéro CE : 218-362-5
• Numéro MDL: MFCD00005166
• Code UNSPSC : 12352209
• ID de substance PubChem : 24278205
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Essai: ≥99%
• Forme: powder
• Chaîne SMILES: OC(=O)[C@@H]1CCN1
• InChI: 1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
• Clé InChI: IADUEWIQBXOCDZ-VKHMYHEASA-N

Description

Description générale

L-Azetidine-2-carboxylic acid is a non-protein amino acid and teratogenic agent. It is toxic in nature.[1]

Application

L-Azetidine-2-carboxylic acid has been used as a:

• collagen synthesis inhibitor[2]
• protein folding antagonist[3]
• as a standard in liquid chromatography-mass spectrometry[1]

Actions biochimiques/physiologiques

Azetidine-2-carboxylic acid (AZC) triggers protein aggregation or upregulates the expression of an aggregation-prone mutant protein, upon interference with nascent protein folding.[4][5]

L-Azetidine-2-carboxylic acid is an inhibitor of collagen synthesis that is anti-angiogenic.

L-Azetidine-2-carboxylic acid is an inhibitor of collagen synthesis that is anti-angiogenic. It is a four-membered ring analog of L-proline that causes protein misconstruction when incorporated instead of proline.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)