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Merck
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76308

Sigma-Aldrich

Pefabloc® TH

acetate salt, ≥90% (HPLC)

Synonyme(s) :

4-Amidino-Nα-(naphthalene-2-sulfonylglycyl)-DL-phenylalanine-piperidide acetate salt, NAPAP

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About This Item

Formule empirique (notation de Hill):
C27H31N5O4S · C2H4O2
Poids moléculaire :
581.68
Numéro MDL:
MFCD01311055
Code UNSPSC :
12352202
ID de substance PubChem :
329767027

Source biologique

synthetic

Pureté

≥90% (HPLC)

Forme

flakes
powder or crystals

Chaîne SMILES 

CC(O)=O.NC(=N)c1ccc(CC(NC(=O)CNS(=O)(=O)c2ccc3ccccc3c2)C(=O)N4CCCCC4)cc1

InChI

1S/C27H31N5O4S.C2H4O2/c28-26(29)21-10-8-19(9-11-21)16-24(27(34)32-14-4-1-5-15-32)31-25(33)18-30-37(35,36)23-13-12-20-6-2-3-7-22(20)17-23;1-2(3)4/h2-3,6-13,17,24,30H,1,4-5,14-16,18H2,(H3,28,29)(H,31,33);1H3,(H,3,4)

Clé InChI

ZBMVAFLDTKWMBP-UHFFFAOYSA-N

Informations sur le gène

human ... F2(2147) , PLAT(5327) , PLG(5340) , PRSS1(5644)

Application

Thrombin inhibitor; used in 3-D modeling of snake venom serine proteases to elucidate the differences with thrombin in their inhibitory domains.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations légales

Pefabloc is a registered trademark of Pentapharm

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Gilad Reuveni et al.
Neuroreport, 28(17), 1176-1179 (2017-09-16)
Thrombin is a coagulation factor implicated in various pathological and physiological processes in the brain, exerting beneficial and deleterious effects in a concentration-dependent manner. Measurement of thrombin activity levels in pathological animal models is needed and in some cases, because
Efrat Shavit-Stein et al.
Frontiers in neurology, 9, 1139-1139 (2019-01-22)
Thrombin and its protease-activated receptor 1 (PAR1) are potentially important in peripheral nerve inflammatory diseases. We studied the role of thrombin and PAR1 in rat experimental autoimmune neuritis (EAN), a model of the human Guillain-Barré syndrome (GBS). EAN was induced
Efrat Shavit-Stein et al.
PloS one, 14(7), e0219453-e0219453 (2019-07-06)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombin in diabetic neuropathy. We measured thrombin
Ekaterina Mindel et al.
Journal of neuroscience research, 99(3), 966-976 (2020-12-10)
Many coagulation factor proteases are increased in the brain during ischemic stroke. One of these proteases is plasmin. In this study we established a novel method for direct quantitative measurement of plasmin activity in male mouse brain slices using a
Valery Golderman et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Neural inflammation is linked to coagulation. Low levels of thrombin have a neuroprotective effect, mediated by activated protein C (APC). We describe a sensitive novel method for the measurement of APC activity at the low concentrations found in neural tissue.
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