In powder form, this material may be stored at room temperature. While the solution stability has not been evaluated, stock solutions are expected to be stable at low pH levels when refrigerated at 2 - 8°C. The product is known to degrade gradually, for optimum quality prepare fresh.
72340
Nicotinamide
≥99.5% (HPLC)
Synonyme(s) :
Acide nicotinique amide, Acide pyridine-3-carboxylique amide, Vitamine PP, Vitamine B3
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Sélectionner une taille de conditionnement
100 G
40,50 €
250 G
87,50 €
1 KG
225,00 €
40,50 €
Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
Devis pour commande en gros
Sélectionner une taille de conditionnement
Changer de vue
100 G
40,50 €
250 G
87,50 €
1 KG
225,00 €
About This Item
Formule empirique (notation de Hill) :
C6H6N2O
Numéro CAS:
Poids moléculaire :
122.12
Beilstein:
383619
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352205
ID de substance PubChem :
Nomenclature NACRES :
NA.79
40,50 €
Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
Devis pour commande en gros
Produits recommandés
Source biologique
synthetic
Essai
≥99.5% (HPLC)
Forme
powder or crystals
Résidus de calcination
≤0.2%
Perte
≤0.2% loss on drying, 20 °C (HV)
Couleur
colorless to white
Pf
128-131 °C (lit.)
128-131 °C
Traces d'anions
chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤150 mg/kg
Traces de cations
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
Application(s)
cell analysis
Chaîne SMILES
NC(=O)c1cccnc1
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Clé InChI
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Informations sur le gène
human ... PARP1(142) , SIRT2(22933)
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
Catégories apparentées
Description générale
Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.
Application
Nicotinamide has been used:
- to study its effect on the expression of sirtuin 1[1]
- in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay[2]
- in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication[3]
Actions biochimiques/physiologiques
Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
302.0 °F - closed cup
Point d'éclair (°C)
150 °C - closed cup
Équipement de protection individuelle
dust mask type N95 (US), Eyeshields, Gloves
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Nicotinamide N-methyltransferase enhances the progression of prostate cancer by stabilizing sirtuin 1
You Z, et al.
Oncology Letters, 15(6), 9195-9201 (2018)
Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival
Lambert HP, et al.
The Journal of biological chemistry, jbc-M114 (2014)
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
Lin Su-Ju and Guarente Leonard
Current Opinion in Cell Biology, 15(2), 241-246 (2003)
Chemical, Biochemical and Medical Aspects, 776-776 null
Human Nutrition, 206-206 (2010)
-
what is the storage temperature 7234 nicotinamide
1 answer-
Helpful?
-
-
How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
-
-
How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
-
Active Filters
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique
