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F6377

Sigma-Aldrich

Fluorescein sodium salt

Powder

Synonyme(s) :

Acid Yellow 73, D&C;Yellow No. 8, NaFl, NaFluo, Sodium fluorescein, Uranine

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About This Item

Formule empirique (notation de Hill):
C20H10Na2O5
Numéro CAS:
518-47-8
Poids moléculaire :
376.27
Numéro C.I. (Colour Index):
45350
Numéro Beilstein :
3833041
Numéro CE :
208-253-0
Numéro MDL:
MFCD00167039
Code UNSPSC :
12171500
ID de substance PubChem :
24894907
Nomenclature NACRES :
NA.47

product name

Fluorescein sodium salt, used as fluorescent tracer

Niveau de qualité

200

Forme

powder

Couleur

orange to brown

pH

8.3 (20 °C, 10 g/L)

Pf

>300 °C

Solubilité

H2O: 1 mg/mL

Densité

0.78 g/cm3 at 29.6 °C (85.3 °F at 699.7 hPa)

Fluorescence

λex 460 nm; λem 515 nm(lit.)

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2

Clé InChI

RGPLGPBQJOQFJS-UHFFFAOYSA-L

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Catégories apparentées

Description générale

Fluorescein is a xanthene dye and is a common labeling agent in biology.

Application

Fluorescein sodium salt has been used as a solute to study microvessel permeability. It has been used as a test molecule to study blood barrier penetration.
Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius. Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes. Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

423.7 °F - Pensky-Martens closed cup

Point d'éclair (°C)

217.6 °C - Pensky-Martens closed cup

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SHBS2708
0000240645
0000150889
0000182362
SHBN9209

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P Kozler et al.
Physiological research, 52(5), 607-614 (2003-10-11)
The aim was to study the blood-brain permeability according to the distribution in the rat brain of Evans blue (EB) and sodium fluorescein (NaFl) administered by an intracarotid injection. Eighteen animals were divided into six groups according to the state
Temperature dependence of electronic parameters of organic Schottky diode based on fluorescein sodium salt.
Yahia IS, et al.
Synthetic Metals, 161(9), 881-887 (2011)
D Montermini et al.
The Journal of physiology, 543(Pt 3), 959-975 (2002-09-17)
The permeability, P(S), to sodium fluorescein (Stokes-Einstein radius = 0.45 nm) has been measured in single mesenteric capillaries of pithed frogs and anaesthetised rats as perfusion velocity, U, was varied over a range from 400 up to 2000-10,000 microm s(-1).
Dimitris N Xanthos et al.
Molecular pain, 8, 44-44 (2012-06-21)
Changes in the blood-central nervous system barriers occur under pathological conditions including inflammation and contribute to central manifestations of various diseases. After short-lasting peripheral and neurogenic inflammation, the evidence is mixed whether there are consistent blood-spinal cord changes. In the
The acute and chronic toxicity of two xanthene dyes, fluorescein sodium salt and phloxine B, to Daphnia pulex.
Walthall WK and Stark JD.
Environmental Pollution (Barking, Essex : 1987), 104(2), 207-215 (1999)
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