10652202001
Roche
Transferrin
from human serum
Synonyme(s) :
serum glycoprotein, transferrin
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About This Item
Code UNSPSC :
12352207
Produits recommandés
Niveau de qualité
Stérilité
0.2 μm filtered
Forme
solution
Conditionnement
pkg of 20 mL (30 mg/ml)
Fabricant/nom de marque
Roche
Technique(s)
cell culture | mammalian: suitable
Couleur
clear red
Solubilité
water: miscible
Numéro d'accès UniProt
Température de stockage
2-8°C
Informations sur le gène
human ... TF(7018)
Description générale
Transferrin is a serum glycoprotein that participates in the transport of iron from absorption and storage sites to tissue cells. The iron-bound transferrin, also referred to as ferrotransferrin, binds to specific cell surface receptors on growing cells and are internalized by endocytosis. Once inside, the iron is released into the cells and the iron-free transferrin, also referred to as apotransferrin, is exocytosed outside the cell without being degraded.
Application
Transferrin, similar to insulin, is a component of most serum-free media formulations. The main function of transferrin is to transport iron into cells by receptor-mediated endocytosis.
Transferrin from human serum has been used as a supplement in:
Transferrin from human serum has been used as a supplement in:
- differentiation medium
- keratinocyte medium
- haemogenic endothelium culture medium
- embryoid-body medium
- blast colony forming cell-culture medium
Forme physique
Solution, 30 mg/ml in IMDM, filtered through 0.2 μm pore size membrane. Iron saturation is below 1%. This product is Apo-Transferrin.
Notes préparatoires
Working concentration: 1 to 100 μg/ml
Stockage et stabilité
Store at 2 to 8 °C. (lyophilizate and solution)
Autres remarques
For life science research only. Not for use in diagnostic procedures.
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
No data available
Point d'éclair (°C)
No data available
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At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to
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