GF037

Thrombopoietin

TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation & maturation of megakaryocytes & promotes increased circulating levels of platelets in vivo.

• Synonyme(s) : TPO
• Code UNSPSC : 12352202
• eCl@ss : 32160405
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Pureté: >98% (SDS-PAGE and HPLC)
• Activité spécifique: ≥1x10(e6) U/mg
• Fabricant/nom de marque: Chemicon^®
• Technique(s): cell culture | mammalian: suitable
• Impuretés: <0.1 ng/mg Endotoxin (of human TPO; 1 EU/μg)
• Entrée: sample type hematopoietic stem cell(s)
• Numéro d'accès NCBI: NM_000460.2; NM_199228.1; NM_199356.1
• Numéro d'accès UniProt: P40225
• Conditions d'expédition: dry ice
• Informations sur le gène: human ... TPO(7173)

Description

Description générale

Product Source: E.coli

TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. Chemicon′s Human TPO is a soluble 18.5 kDa protein containing 174 amino acid residues which comprises the receptor binding domain of the Mpl-ligand protein.

Actions biochimiques/physiologiques

The ED50 was determined by the dose-dependent stimulation of the proliferation of M07e cells is ≤1.0 ng/mL

Forme physique

Lyophilized protein from 5mM Tris, pH 7.6, with no additives.

Stockage et stabilité

The lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other aqueous buffers and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted TPO should be stored in working aliquots at -20°C.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1