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553211

Sigma-Aldrich

Rapamycin

≥95% (HPLC), solution, mTOR inhibitor, Calbiochem

Synonyme(s) :

InSolution Rapamycin, mTOR Inhibitor I

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500 μG
235,00 €
1 MG
353,00 €

235,00 €

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500 μG
235,00 €
1 MG
353,00 €

About This Item

Formule empirique (notation de Hill) :
C51H79NO13
Poids moléculaire :
914.17
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

235,00 €

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Devis pour commande en gros

Nom du produit

Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

Niveau de qualité

100

Essai

≥95% (HPLC)

Forme

solution

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

desiccated (hygroscopic)
protect from light

Conditions d'expédition

wet ice

Température de stockage

−20°C

Description générale

Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Mammalian target of rapamycin (mTOR)
Product does not compete with ATP.
Reversible: no
Target IC50: 50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

2.5 mg/mL solution in DMSO (2.74 mM)

Reconstitution

Following initial use, aliquot and freeze (-20°C).

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Point d'éclair (°C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Rachel M Wise et al.
Cells, 9(10) (2020-10-04)
Human adipose-derived stem cells (ASCs) show immense promise for treating inflammatory diseases, attributed primarily to their potent paracrine signaling. Previous investigations demonstrated that short-term Rapamycin preconditioning of bone marrow-derived stem cells (BMSCs) elevated secretion of prostaglandin E2, a pleiotropic molecule
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Esmaeilian, et al.
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Nascent RNA sequencing has revealed that pre-mRNA splicing can occur shortly after introns emerge from RNA polymerase II (RNA Pol II). Differences in co-transcriptional splicing profiles suggest regulation by cis- and/or trans-acting factors. Here, we use single-molecule intron tracking (SMIT)
Clarissa Braun et al.
Cell stress, 5(12), 176-182 (2021-12-18)
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory processes. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). However, additional pathways that
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Methods in molecular biology (Clifton, N.J.), 2442, 463-474 (2022-03-24)
The β-galactoside-binding protein Galectin-9 (Gal-9) functions as a double-edged sword during HIV infection. On the one hand, Gal-9 can reactivate HIV latently infected cells, the main barrier to achieving HIV eradication, making them visible to immune clearance. On the other
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Questions

  1. What is the volume of the product?

    1 answer

    1. This product is a 5 mM (500 µg/109 µl) solution of Rapamycin in DMSO. The 1 mg pack size should have approximately 218 µl.

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