540217

PTP LYP Inhibitor

The PTP LYP Inhibitor controls the biological activity of PTP LYP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : PTP LYP Inhibitor, (2-pyridine)(Ph)₂P-Au-Cl, HePTP Inhibitor III, PTP Inhibitor XXVIII, PTP-PEST Inhibitor
• Formule empirique (notation de Hill): C₁₇H₁₄AuClNP
• Poids moléculaire : 495.69
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A cell-permeable, Au(I)-phosphine complex that acts as selective inhibitor of lymphoid tyrosine phosphatase (LYP) (IC₅₀= 1.5 µM) and has a ~10-fold selectivity for LYP over PTP-PEST, HePTP, and CD45 in both JTAg cells and primary mouse thymocytes.

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Karver, M.R., et al. 2009. J. Med. Chem.52, 6912.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable