890700P
Avanti
12:0 EPC (Cl Salt)
Avanti Research™ - A Croda Brand 890700P, powder
Synonyme(s) :
1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt)
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About This Item
Formule empirique (notation de Hill):
C34H69NO8PCl
Numéro CAS:
Poids moléculaire :
686.34
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Forme
powder
Conditionnement
pkg of 1 × 10 mg (890700P-10mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 890700P
Type de lipide
cationic lipids
transfection
Conditions d'expédition
dry ice
Température de stockage
−20°C
Chaîne SMILES
O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)OCC.[Cl-]
Catégories apparentées
Description générale
1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is a cationic phospholipid. 12:0 EPC is a short-chain analog of dioleoyl ethylphosphatidylcholine. O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.
Application
1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC (Cl Salt)) is suitable for use in lipoplex preparation and to study the lipoplex transfection activity. It might also be used in lipid mixtures to study its cubic phases of formation, stability and phase transitions.
Actions biochimiques/physiologiques
1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is preferred for transfection of cultured primary endothelial cells. 12:0 EPC forms lamellar lipoplexes possessing high to superior transfection activity. Chemically synthesized cationic lipids are applicable as non-viral gene carriers. Variation in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency.
Conditionnement
5 mL Clear Glass Sealed Ampule (890700P-10mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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Li Wang et al.
Biophysical journal, 91(10), 3692-3706 (2006-08-29)
A combination of two cationic lipid derivatives having the same headgroup but tails of different chain lengths has been shown to have considerably different transfection activity than do the separate molecules. Such findings point to the importance of investigating the
Analysis of lipoplex structure and lipid phase changes
Liposomes, 399-423 (2010)
Boris Tenchov et al.
Chemistry and physics of lipids, 208, 65-74 (2017-10-07)
The non-lamellar phases formed by membrane lipids in diluted aqueous dispersions are mainly represented by the inverted hexagonal phase, HII, and phases of cubic symmetry, among them the bicontinuous cubic phases Pn3m (Q224), Im3m (Q229) and Ia3d (Q230). Here we
Rumiana Koynova et al.
The journal of physical chemistry. B, 111(27), 7786-7795 (2007-06-19)
Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids, such as dimethylammonium bromides and trimethylammonium propanes, deliver therapeutic DNA considerably more efficiently than do the separate molecules. In an effort to
Rumiana Koynova et al.
Biochimica et biophysica acta, 1768(2), 375-386 (2006-12-13)
Lipoplexes containing a mixture of cationic phospholipids dioleoylethylphosphatidylcholine (EDOPC) and dilauroylethylphosphatidylcholine (EDLPC) are known to be far more efficient agents in transfection of cultured primary endothelial cells than are lipoplexes containing either lipid alone. The large magnitude of the synergy
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