Diabetogenic effects of various analogues of 8-aminoquinoline were studied. Out of 10 compounds investigated only three showed diabetogenic properties: 8-(p-tolylsulfonylamino)-quinoline, 8-(p-benzenesulfonylamino)-quinoline and 8-(p-methylsulfonylamino)-quinoline. After the injection of these compounds a long term persistent hyperglycemia took place in rabbits and also
Biulleten' eksperimental'noi biologii i meditsiny, 114(11), 491-492 (1992-11-01)
The action of immunosuppressive agent ciclosporin A on the insular apparatus was studied with an original method of cytochemical zinc detection in experiments on mice. The drug was found to lower zinc levels in pancreatic beta-cells. In ciclosporin A pretreatment
Zinc content in pancreatic islet cells and hippocampus was studied with the aid of highly sensitive selective cytochemical reaction of 8-(p-toluensulfonylamino)-quinoline. It was shown that the factors stimulating B-insulocyte secretory activity induced the decrease of this metal concentrations in the
Biulleten' eksperimental'noi biologii i meditsiny, 111(2), 135-137 (1991-02-01)
The injections of diabetogenic drugs to rabbits induced a decrease in zinc and calcium content in B insulocytes dependent on the degree of these cells damage and hyperglycemia. The content of these metals in A insulocytes was not significantly altered
A method for cytochemical detection of zinc in peripheral blood granulocytes with selective reaction of 8-(p-toluenesulfonyl amino)-quinoline was developed. Zinc levels in granular leukocytes were found reduced in chronic myeloleukemia and elevated in leukemoid reactions. The method may be used
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